Structure of Francisella tularensis AcpA

Structure of Francisella tularensis AcpA: prototype of a unique superfamily of acid phosphatases and phospholipases C.

AcpA is a respiratory burst-inhibiting acid phosphatase from the Centers for Disease Control and Prevention Category A bioterrorism agent Francisella tularensis and prototype of a superfamily of acid phosphatases and phospholipases C. We report the 1.75-A resolution crystal structure of AcpA complexed with the inhibitor orthovanadate, which is the first structure of any F. tularensis protein an...

Crystallization of AcpA, a respiratory burst-inhibiting acid phosphatase from Francisella tularensis.

Francisella tularensis is a highly infectious bacterial pathogen that is classified as a Category A Pathogen by the Centers for Disease Control and Prevention. Here, we report crystallization of a recombinant form of F. tularensis AcpA, a unique and highly expressed acid phosphatase that is thought to play a role in intracellular survival by inhibiting the host respiratory burst. Three crystal ...

Francisella tularensis

Francisella tularensis: an Overview

F rancisella tularensis was first isolated in 1912 from rodents suffering from a plague-like disease in Tulare County, Calif. Subsequently, investigators learned that this small, gram-negative bacterium infects many animal species and is associated with a wide range of diseases. In humans, the bacterium causes a serious, sometimes fatal disease, called tularemia, which is also known as rabbit f...

Etymologia: Francisella tularensis

IA. The ultrastructural characteristics of Francisella tularensis interaction with Tetrahymena pyriformis. Biological diversity versus risk for mosquito nuisance and disease transmission in constructed wetlands in southern Sweden.fer K. Detection of Francisella tularensis in Alaskan mosquitoes (Diptera: Culicidae) and assessment of a laboratory model for transmission. The present distribution a...